Cancer symptoms can vary depending on the type and stage of the disease, but some common symptoms are shared across many forms of cancer. Fatigue, for instance, is a prevalent symptom that can be severe and persistent, often not relieved by rest. Unexplained weight loss of 10 pounds or more might occur, which is often an early sign of cancer, particularly cancers of the pancreas, stomach, esophagus, or lung. Another common symptom is pain, which can be a sign of bone cancer or testicular cancer, although any persistent pain should be evaluated by a healthcare professional.