What are the Implications of LOH for Cancer Treatment?
Understanding LOH can have significant implications for cancer treatment. The identification of LOH events can help in pinpointing critical biomarkers for early diagnosis and in tailoring personalized therapies. For example, cancers with LOH in BRCA1 or BRCA2 are often sensitive to PARP inhibitors, a class of drugs that target DNA repair pathways. Additionally, LOH can indicate a tumor's propensity for genetic instability, guiding the use of treatments that target rapidly evolving cancer cells.
