What Are the Implications of Ultramutation for Cancer Treatment?
The high mutation burden of ultramutated cancers can make them more recognizable to the immune system, which can be advantageous for immunotherapy. Treatments such as immune checkpoint inhibitors, including PD-1 and CTLA-4 inhibitors, have shown promising results in treating ultramutated cancers. However, the high genetic variability can also lead to drug resistance, making treatment more challenging.
