1. Dual-Targeting Mechanisms: Next generation CAR T cells can recognize multiple antigens on cancer cells, reducing the likelihood of cancer escape mechanisms. 2. Safety Switches: Incorporating "kill switches" or "suicide genes" allows for the controlled elimination of CAR T cells in case of severe adverse reactions. 3. Enhanced Persistence: Modifications in the CAR structure or co-stimulatory domains can improve the longevity and activity of the CAR T cells in the patient’s body.
