What are the Key Mechanisms Driving Proliferation in Cancer?
Several mechanisms drive unchecked proliferation in cancer:
Genetic Mutations: Changes in DNA that affect oncogenes, tumor suppressor genes, and genes involved in DNA repair. Epigenetic Modifications: Changes that affect gene expression without altering the DNA sequence, such as DNA methylation and histone modification. Growth Factors: Increased production or sensitivity to growth factors that promote cell division. Cell Cycle Dysregulation: Malfunctions in the regulatory checkpoints of the cell cycle.
