Despite their advantages, ADCs have some limitations: - Complexity in Manufacturing: ADCs are complex molecules that require precise engineering, making them difficult and expensive to produce. - Heterogeneity of Tumors: Not all cancer cells express the target antigen uniformly, which can limit the efficacy of ADCs. - Resistance Mechanisms: Cancer cells can develop resistance mechanisms, such as downregulating the target antigen or altering drug efflux pathways.
