What are the limitations of GTEx in cancer research?
While GTEx provides a wealth of information, it primarily focuses on normal tissues. Therefore, it may not capture all the genetic and molecular alterations present in tumor tissues. Moreover, cancer is a highly heterogeneous disease with significant variability between patients and even within different regions of the same tumor. Thus, while GTEx data is invaluable for baseline comparisons, it must be complemented with cancer-specific datasets for a comprehensive understanding.
