What are the Limitations of the MethylationEPIC BeadChip?
While the MethylationEPIC BeadChip is a powerful tool, it has some limitations: - Limited Coverage of Non-CpG Methylation: The platform primarily focuses on CpG sites, potentially missing important non-CpG methylation events. - Technical Variability: Although reproducible, some technical variability can still affect the results, necessitating careful experimental design and validation. - Data Interpretation: High-dimensional methylation data require sophisticated bioinformatics tools and expertise for accurate interpretation.
