What Are the Main Types of Anti-Angiogenic Agents?
Several types of anti-angiogenic agents have been developed to target various aspects of the angiogenesis process. These include:
1. VEGF Inhibitors: Drugs like Bevacizumab (Avastin) specifically target VEGF, blocking its interaction with receptors on endothelial cells. 2. Receptor Tyrosine Kinase Inhibitors (RTKIs): These drugs, such as Sunitinib and Sorafenib, inhibit multiple tyrosine kinases involved in angiogenesis and tumor growth. 3. Integrin Inhibitors: These agents target integrins, proteins on the surface of cells that play a role in cell adhesion and migration, crucial for new blood vessel formation. 4. Matrix Metalloproteinase Inhibitors (MMPIs): MMPs are enzymes that break down the extracellular matrix, a necessary step for new blood vessels to form. Inhibitors of these enzymes can, therefore, impede angiogenesis.
