What are the Mechanisms by which Inflammation Promotes Cancer?
Inflammation promotes cancer through several mechanisms:
DNA Damage: Inflammatory cells produce reactive oxygen species (ROS) and reactive nitrogen species (RNS) that can damage DNA. Proliferation: Cytokines like IL-6 and TNF-α promote cellular proliferation, which can lead to tumor formation. Inhibition of Apoptosis: Inflammatory signals can inhibit apoptosis, allowing damaged cells to survive and proliferate. Angiogenesis: Inflammatory cytokines can stimulate the growth of new blood vessels, supplying the tumor with nutrients and oxygen.
