What Are the Potential Limitations and Risks of Using Ketone Bodies in Cancer Therapy?
While the use of ketone bodies and the ketogenic diet in cancer therapy has shown promise, there are several limitations and risks to consider: 1. Tumor Heterogeneity: Cancer cells within the same tumor can exhibit diverse metabolic profiles, potentially leading to variable responses to ketone bodies. 2. Nutritional Deficiencies: Strict adherence to the ketogenic diet can result in nutritional imbalances and deficiencies, which may adversely affect overall health. 3. Side Effects: The ketogenic diet can cause side effects such as gastrointestinal discomfort, fatigue, and increased cholesterol levels. 4. Clinical Evidence: While preclinical studies are encouraging, more rigorous clinical trials are necessary to establish the efficacy and safety of ketone bodies and the ketogenic diet in cancer therapy.
