What are the Potential Mechanisms by which ACE Inhibitors May Affect Cancer?
Several mechanisms have been proposed to explain how ACE inhibitors might influence cancer development and progression:
Anti-Angiogenesis: By reducing the levels of angiotensin II, ACE inhibitors may decrease the formation of new blood vessels that tumors need for growth and metastasis. Anti-Inflammatory Effects: ACE inhibitors may reduce inflammation, which is a known risk factor for various cancers. Cell Proliferation: Angiotensin II has been shown to promote cell proliferation, so inhibiting its production may slow down the growth of cancer cells. Apoptosis: ACE inhibitors may promote apoptosis (programmed cell death) in cancer cells, thereby inhibiting tumor growth.
