What Are the Potential Mechanisms Linking Cholesterol to Cancer?
Several mechanisms may explain the link between high cholesterol and cancer:
1. Cell Membrane Fluidity: Cholesterol is a major component of cell membranes, affecting their fluidity and the function of membrane-bound proteins involved in cell signaling and growth. 2. Inflammation: High cholesterol levels can lead to chronic inflammation, a known risk factor for cancer development. 3. Oxidative Stress: Oxidized cholesterol can generate reactive oxygen species (ROS), which cause DNA damage and contribute to cancer initiation and progression. 4. Signaling Pathways: Cholesterol can activate oncogenic signaling pathways, such as the Hedgehog and PI3K/Akt pathways, promoting cell survival and proliferation.
