Symptoms can vary depending on the location and extent of the metastasis but often include: - Bone Pain: Often the first symptom and can be severe. - Fractures: Bones weakened by metastasis are more prone to breaks. - Spinal Cord Compression: Can occur if the cancer spreads to the spine, leading to pain, numbness, or paralysis. - Hypercalcemia: Elevated calcium levels in the blood due to bone breakdown, which can cause nausea, vomiting, thirst, constipation, and confusion.