What Are the Treatment Implications for FANCI-Deficient Cancers?
For cancers with FANCI deficiencies, exploiting the impaired DNA repair mechanism is a therapeutic strategy. Drugs like PARP inhibitors work on the principle of synthetic lethality, where they further inhibit the already compromised DNA repair pathways, leading to cancer cell death. This approach is particularly beneficial in cancers with BRCA mutations, which also share similar DNA repair deficiencies.
