Treatment options for GIST depend on the size and location of the tumor, as well as whether it has spread to other parts of the body. Common treatments include: - Surgery: The primary treatment for localized GIST is surgical removal of the tumor. - Targeted Therapy: Drugs like imatinib (Gleevec) are used to block the activity of the mutated KIT or PDGFRA proteins. This treatment is particularly effective for unresectable or metastatic GIST. - Radiation Therapy: While not commonly used, radiation therapy may be considered in certain cases. - Chemotherapy: Traditional chemotherapy is generally not effective against GIST and is rarely used.