The primary treatment for localized GISTs is surgical resection, aiming to remove the tumor completely. For unresectable or metastatic GISTs, targeted therapy with tyrosine kinase inhibitors (TKIs) such as imatinib, sunitinib, and regorafenib is the standard approach. These drugs inhibit the activity of the mutated KIT or PDGFRA proteins, slowing tumor growth and progression.
