VEGF inhibitors are a class of medications designed to block the activity of Vascular Endothelial Growth Factor (VEGF), a signal protein that stimulates the formation of blood vessels. This process, known as angiogenesis, is crucial in both normal and pathological conditions, including the growth of cancerous tumors. By inhibiting VEGF, these drugs aim to starve tumors of the blood supply they need to grow and metastasize.