Several factors contribute to biomarker variability:
- Genetic Differences: Individual genetic makeup can influence the expression and function of biomarkers. - Environmental Factors: Lifestyle, diet, and exposure to toxins can affect biomarker levels. - Tumor Heterogeneity: Cancer cells within the same tumor or between primary and metastatic sites can exhibit different biomarker profiles. - Temporal Changes: Biomarker levels can change over the course of the disease or in response to treatment.