The exact mechanisms behind cancer-related cachexia are not entirely understood, but it is believed to be caused by a combination of factors. These include systemic inflammation, metabolic abnormalities, and the direct effects of tumors. Tumor-derived factors such as proteolysis-inducing factor (PIF) and inflammatory cytokines like TNF-α, IL-6, and IFN-γ play a significant role in the catabolic processes.
