Several factors can contribute to graft failure. These include:
Poor graft quality: If the transplanted cells are of low quality or insufficient quantity, they may not engraft properly. Host immune response: The recipient's immune system may attack the transplanted cells, leading to failure. Infections: Post-transplant infections can damage the new graft. Drug toxicity: Medications used during and after the transplant process can sometimes harm the graft. Graft-versus-host disease (GVHD): In allogeneic transplants, the donor cells may attack the recipient's body, leading to graft failure.
