humoral hypercalcemia of malignancy (hhm)

What Causes HHM?

The primary cause of HHM is the secretion of parathyroid hormone-related protein (PTHrP) by the tumor cells. PTHrP mimics the action of parathyroid hormone, leading to increased bone resorption and renal tubular calcium reabsorption, which results in elevated blood calcium levels. Other factors that can contribute include increased production of Vitamin D analogs by lymphomas and the direct osteolytic activity of bone metastases.

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