Several factors can cause irritation in cancer patients: - Tumor Growth: Tumors can press against nerves or tissues, causing pain and discomfort. - Inflammation: The body's immune response to cancer can lead to chronic inflammation. - Cancer Treatments: Treatments like chemotherapy, radiotherapy, and immunotherapy can cause side effects such as skin irritation, mucositis, and gastrointestinal discomfort. - Secondary Infections: Cancer can compromise the immune system, leading to infections that cause irritation.