Unintended immune activation can be caused by several factors, including the following:
Checkpoint Inhibitors: These drugs block proteins that prevent the immune system from attacking cancer cells. However, they can also cause the immune system to attack normal tissues. Cytokine Release Syndrome: A common side effect of CAR-T cell therapy, where the rapid activation of immune cells leads to the excessive release of cytokines, causing severe inflammation. Cross-reactivity: When the immune system mistakenly targets normal cells that share antigens with cancer cells.
