What Challenges does GATK Address in Cancer Genomics?
GATK addresses several challenges in cancer genomics, including:
Heterogeneity: Tumors are often heterogeneous, containing a mix of different cell populations. GATK's robust algorithms help in accurately calling variants in such complex samples. Low-frequency mutations: Some mutations may be present at low frequencies within a tumor. GATK's sensitive detection capabilities ensure that even these mutations are identified. Data noise: High-throughput sequencing data can be noisy. GATK includes sophisticated filtering and recalibration steps to minimize false positives and false negatives.
