What Challenges Exist in Using TILs for Cancer Treatment?
Despite their potential, several challenges exist in utilizing TILs for cancer treatment. One major challenge is the variability in TIL response across different patients and tumor types. Additionally, tumors can develop mechanisms to evade immune detection, such as through the expression of immune checkpoint molecules like PD-L1, which can inhibit TIL activity. Overcoming these challenges requires further research and the development of combination therapies that enhance TIL efficacy.
