What Characterizes Luminal A and Luminal B Subtypes?
Luminal A subtype is characterized by the expression of estrogen receptor (ER) and progesterone receptor (PR), but low levels of the protein Ki-67, which is a marker of proliferation. This subtype tends to have a better prognosis and is often treated with hormone therapy.
Luminal B subtype also expresses ER and PR but has higher levels of Ki-67, indicating a higher proliferation rate. This subtype may also express the human epidermal growth factor receptor 2 (HER2). Treatment for Luminal B often includes a combination of hormone therapy and chemotherapy.
