High platelet counts, known as thrombocytosis, can also be significant: - Cancer-Related Inflammation: Some cancers can cause chronic inflammation, leading to elevated platelet counts. - Paraneoplastic Syndromes: These are rare disorders triggered by an immune response to a malignancy, which can sometimes result in high platelet counts. - Risk of Blood Clots: Elevated platelet levels increase the risk of blood clot formation, which can lead to complications like deep vein thrombosis (DVT) or pulmonary embolism.