Several factors can influence drug efficacy, including:
1. Genetic Mutations: The presence of specific genetic mutations can render certain drugs more or less effective. For example, drugs targeting the HER2 protein are particularly effective in HER2-positive breast cancer. 2. Tumor Microenvironment: The surrounding cells, blood vessels, and signaling molecules in the tumor can impact drug delivery and effectiveness. 3. Patient Characteristics: Age, overall health, and previous treatments can also affect how well a drug works. 4. Drug Resistance: Over time, cancer cells can develop resistance to a drug, reducing its efficacy. This is a significant challenge in long-term cancer management.
