Several factors can influence PSA levels, including age, race, medications, and certain medical procedures. For example, older men tend to have higher PSA levels. Additionally, African American men often have higher PSA levels than men of other races. Medications used to treat benign prostate conditions, such as 5-alpha reductase inhibitors, can lower PSA levels. Procedures like a digital rectal exam or a prostate biopsy can temporarily elevate PSA levels.