Several factors can influence the ability of a tumor to penetrate tissues:
- Tumor Microenvironment: The surrounding environment, including stromal cells, immune cells, and the ECM, can either promote or inhibit tumor penetration. - Genetic Mutations: Certain genetic alterations can make cancer cells more aggressive and capable of penetrating tissues. - Hypoxia: Low oxygen levels within tumors can lead to the activation of pathways that promote invasion and metastasis.
