Cockayne Syndrome (CS) is a rare genetic disorder characterized by growth failure, neurological impairment, and premature aging. It is caused by mutations in genes responsible for DNA repair, primarily ERCC6 (CSB) and ERCC8 (CSA). These genes are involved in the transcription-coupled repair (TCR) pathway, which is a specialized sub-pathway of nucleotide excision repair (NER) that specifically rectifies DNA damage in actively transcribed genes.
