Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is a member of the herpesvirus family. It is primarily known for its role in causing Kaposi's sarcoma (KS), a type of cancer that forms in the lining of blood and lymph vessels. HHV-8 is also associated with other lymphoproliferative disorders and cancers, such as primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD).