Isocitrate Dehydrogenase 2 (IDH2) is an enzyme that plays a crucial role in cellular metabolism. It is involved in the citric acid cycle, where it catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate. Mutations in the IDH2 gene can lead to the production of an oncometabolite, 2-hydroxyglutarate (2-HG), which is associated with various cancers.
