3-Phosphoinositide-dependent protein kinase-1 (PDK1) is a critical enzyme in the PI3K/AKT signaling pathway, which plays a significant role in regulating cell growth, proliferation, and survival. PDK1 is responsible for activating a variety of downstream targets, including AKT, by phosphorylating them. Given its pivotal role, PDK1 is often upregulated in various cancers, making it a potential target for therapeutic intervention.
