What is the Clinical Relevance of Immune Hotspots?
Immune hotspots can have significant clinical implications. For example, the presence of a high density of cytotoxic T cells within these hotspots is often associated with better prognosis and response to immunotherapy. Conversely, the presence of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) can indicate an immunosuppressive environment that may hinder the effectiveness of treatment.
