What is the Current State of Clinical Applications?
Several LNP-based formulations are currently in clinical trials or have been approved for use. For instance, the FDA-approved Onivyde, a liposomal formulation of irinotecan, is used for the treatment of metastatic pancreatic cancer. Additionally, mRNA vaccines for COVID-19, such as those developed by Pfizer-BioNTech and Moderna, utilize LNPs for delivery, showcasing the potential for similar technologies to be adapted for cancer therapy.
