What is the Impact of Genetic Instability in Cancer?
Genetic instability refers to an increased rate of mutations within the genome. This can result from defects in DNA repair mechanisms, such as those involving BRCA1 and BRCA2 genes. High levels of genetic instability can lead to the accumulation of mutations that drive cancer progression, making the disease more aggressive and harder to treat. It also contributes to tumor heterogeneity, complicating treatment strategies.
