What is the Impact of Tumor Microenvironment on Feedback Mechanisms?
The tumor microenvironment consists of non-cancerous cells, signaling molecules, and the extracellular matrix surrounding the tumor. It can influence feedback mechanisms significantly. For example, hypoxia (low oxygen levels) in the tumor microenvironment can activate hypoxia-inducible factors (HIFs) that promote angiogenesis and alter metabolic pathways, creating a positive feedback loop that supports tumor growth and survival.
