What is the mechanism of PFC-induced carcinogenesis?
PFCs are known to interfere with various biological processes. They can bind to and activate the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors, which are involved in the regulation of cell growth, differentiation, and inflammation. Activation of these receptors can lead to changes in gene expression that may promote cancer development. Additionally, PFCs can generate oxidative stress and induce DNA damage, further contributing to their carcinogenic potential.
