The NCDB is a nationwide oncology outcomes database that collects data from CoC-accredited cancer programs. It is one of the largest clinical cancer registries in the world, containing data on millions of cancer cases. The NCDB is a powerful tool for research, quality improvement, and benchmarking, allowing cancer programs to compare their performance with national standards and identify areas for improvement. Data from the NCDB is used to inform evidence-based guidelines, policy decisions, and clinical practice.