What is the Prognostic Value of Cadherins in Cancer?
The expression levels of cadherins, particularly E-cadherin, can serve as prognostic markers. Reduced E-cadherin expression is often correlated with higher tumor grade, increased invasiveness, and worse outcomes in a variety of cancers, including breast, gastric, and prostate cancers. Conversely, the presence of N-cadherin is generally indicative of a more aggressive tumor phenotype.
