leland hartwell

What is the Role of CDC Genes in Cancer?

CDC genes, first discovered by Hartwell in yeast, have homologs in humans that play similar roles in cell cycle regulation. Mutations in these genes can lead to unchecked cell division and tumor formation. For instance, the human homolog of CDC28, known as CDK1, is frequently dysregulated in various cancers. Understanding the function of these genes has been instrumental in identifying potential biomarkers and therapeutic targets in oncology.

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