What is the Role of Genetic Polymorphisms in GSTs?
Genetic polymorphisms in GST genes can significantly affect an individual's susceptibility to cancer and their response to chemotherapy. Polymorphisms can lead to variations in enzyme activity, influencing the detoxification capacity of the cells. For example, the GSTM1 and GSTT1 null polymorphisms, where the genes are deleted, are associated with an increased risk of developing certain types of cancer due to reduced detoxification of carcinogens.
