The role of TNF receptors in cancer is complex and context-dependent. On one hand, TNF can induce apoptosis in cancer cells, acting as a potential anti-tumor agent. On the other hand, chronic TNF signaling can promote inflammation and tumor progression. Overexpression of TNFR1 and TNFR2 has been observed in various cancers, and their signaling pathways are often dysregulated.
