Vascular Endothelial Growth Factor (VEGF) is a signal protein that stimulates the formation of blood vessels. It plays a crucial role in both normal and pathological conditions, including angiogenesis, which is the growth of new blood vessels from pre-existing vessels. In cancer, VEGF is often overexpressed, leading to the formation of a dense network of blood vessels that supply nutrients and oxygen to tumors, facilitating their growth and metastasis.