What Makes Afatinib Different from Other EGFR Inhibitors?
Unlike first-generation EGFR inhibitors such as gefitinib and erlotinib, afatinib irreversibly binds to EGFR, HER2, and HER4 receptors. This irreversible binding provides a broader and more sustained inhibition of these pathways. Additionally, afatinib has shown efficacy in some cases where tumors have developed resistance to first-generation EGFR inhibitors.
