What mechanisms do MDSCs use to suppress the immune system?
MDSCs employ multiple mechanisms to exert immunosuppression, including: - Arginase I and inducible nitric oxide synthase (iNOS), which deplete essential amino acids like arginine, inhibiting T cell function. - Reactive oxygen species (ROS) and nitric oxide (NO), which induce apoptosis in T cells. - Immunosuppressive cytokines such as IL-10 and TGF-β, which inhibit the activity of other immune cells. - Induction of regulatory T cells (Tregs), which further suppress immune responses.
