What Role Do Epigenetics Play in Aberrant Gene Expression?
Epigenetics involves heritable changes in gene expression that do not involve changes to the underlying DNA sequence. In cancer, epigenetic alterations such as hypermethylation of tumor suppressor genes or hypomethylation of oncogenes can result in abnormal gene expression. Epigenetic therapies, such as DNA methyltransferase inhibitors and histone deacetylase inhibitors, are being explored to reverse these changes.
