What Role Do Non-Coding RNA Transcripts Play in Cancer?
Non-coding RNA (ncRNA) transcripts, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been implicated in cancer. These molecules do not code for proteins but can regulate gene expression at various levels. miRNAs can act as oncogenes or tumor suppressors by targeting mRNAs for degradation or translational repression. lncRNAs can modulate chromatin structure and gene transcription. Dysregulation of ncRNAs is often observed in cancer and can contribute to tumorigenesis.
